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SURMOUNT-5, the first head-to-head trial (published in NEJM, 2025), found tirzepatide produced about 20.2% average weight loss versus 13.7% for semaglutide over 72 weeks

The reality is that traditional weight loss methods often fail to address the biological, psychological, and social complexities that influence long-term weight gain

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Neuro Endocrinol Lett 32:13340, PMID: 21552194 Kaddurah-Daouk R, Yuan P, Boyle SH, Matson W, Wang Z, Zeng ZB, Zhu H, Dougherty GG, Yao JK, Chen G, Guitart X, Carlson PJ, Neumeister A, Zarate C, Krishnan RR, Manji HK, Drevets W (2012) Cerebrospinal fluid metabolome in mood disorders-remission state has a unique metabolic profile