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The questions that Phase 3 will need to answer and that regulators will scrutinize closely include cardiovascular outcomes over extended periods, liver function changes beyond the 48-week window, potential interactions with other metabolic agents, and safety in populations not well-represented in Phase 2

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For instance, those with GI disease, a history of gallbladder disease, a high risk for pancreatitis, or kidney and liver issues would likely be advised not to take retatrutide