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1 AUC values shown in this table were calculated directly from each participants concentration-time data using noncompartmental methods, and therefore differ from the model-based estimated mean AUCs reported elsewhere in the manuscript, which were obtained from linear mixed-effects models fitted on log-transformed AUC and back-transformed to the original scale (estimated marginal means)

In the near term, both experts agreed that these findings should not alter prescribing practice for GLP-1 receptor agonists as a CRC prevention strategy in the absence of prospective validation

Yes, and the effect is statistically robust

Specifically, BACE1 is the enzyme that initially chops the amyloid precursor protein (APP) into a form that then undergoes subsequent processing into neurotoxic A40 and A42 oligomers