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Vitamin B12 Supplementation in Diabetic Neuropathy MDPI article: Investigates daily methylcobalamin in type 2 diabetes neuropathy patients with B12 deficiency

Of these seven groups, the Firmicutes , Proteobacteria , and Verrucomicrobia phyla demonstrated a significant main effect of treatment group on relative abundance after BenjaminiHochberg correction for multiple comparisons, while Bacteroidetes and Actinobacteria demonstrated significant main effects of treatment group on relative abundance before BenjaminiHochberg correction

However, because this product provides doses far above the daily nutritional requirements (for instance 100 mg of B vs an RDA of ~1.4 mg), its use in pregnancy must be carefully considered