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Since the participants were discouraged from starting symptomatic therapy during the 52-week, Part 1, double-blind, placebo-controlled period unless deemed clinically essential, most participants experienced motor worsening before starting symptomatic therapy, which may not be replicable in future clinical trials with different study designs or population characteristics

Not seeing weight loss after 6 weeks of semaglutide treatment would be unusual but not necessarily abnormal

Semaglutide does not pharmacologically suppress cortisol production, but it may normalize an overactive stress-response system by calming brain regions that trigger HPA axis activation

GLP-1 receptor agonists, such as semaglutide and tirzepatide , have shown promise in managing PCOS symptoms