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Research published in Cell shows that treatment of naturally aged mice with FOXO4-DRI significantly improved physical performance, with treated animals running approximately double the distance on voluntary running wheels compared to untreated age-matched counterparts

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Beyond these three papers, review articles referencing the human peptides discovery in the 1970s continue to shape how researchers frame new hypotheses, particularly around why plasma concentration declines with age and what that means for tissue-repair capacity over time