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For those on newer medications like semaglutide and tirzepatide specifically, the regain was even steeper, averaging 9.69 kg

Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43

For the side effect phenotypes, we defined separate casecontrol phenotypes for each side effect recorded in the survey, contrasting those who self-rated their side effects as moderate or severe (cases) to those who self-rated their side effects as mild or non-existent (controls)