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Certainly, we were among the first to make that discovery
mGIPR-Ab/GLP-1 treatment of wild-type mice and KO of Gipr in the mouse CNS are both associated with similar downstream changes in gene expression related to cell cycle regulation, cholesterol biosynthesis, ECM and collagen organization, and immune response and inflammation in WAT and liver
Aranda-Rivera AK, Cruz-Gregorio A, Arancibia-Hernndez YL, Hernndez-Cruz EY, Pedraza-Chaverri J
These changes can be reversed by Fer-1, indicating that iron overload induced ferroptosis in HH mice, and suggesting targeting ferroptosis could be a promising strategy for treating hemochromatosis-related injury
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