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Compared to GLP-1, semaglutide carries a substitution of the alanine at position 8 with -aminoisobutyric acid (Aib) and acylation of the lysine at position 26 with a fatty di-acid side chain for extended half-life, which is linked via a linker sequence
Perkovic V, et al
The needles used for GLP-1 and GLP/GIP are tiny, ultra-thin ones
This makes it particularly popular among people with fair skin or those who burn easily in the sun
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