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This could increase pressure on companies to maintain or institute coverage for GLP-1 medications for obesity
In another study conducted in a rat model of metabolic syndrome, chronic treatment with liraglutide showed a greater increase in coronary vessel internal diameter than vehicle control (Sukumaran et al., 2020)
GLP-1 RAs may address this directly Tirzepatide (dual GIP/GLP-1) appears to achieve the greatest weight reduction (1624% in non-diabetic patients) GLP-1 RAs may reduce or enable tapering of systemic immunosuppressants (including methotrexate and biologics) in patients who achieve significant weight loss, reducing cumulative toxicity
Although patients with type 2 diabetes may eventually require insulin, interventions that enhance insulin sensitivity may be used to maintain normal blood glucose concentrations
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