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mTORC1 Activator SLC38A9 is required to efflux essential amino acids from lysosomes and use protein as a nutrient

While our data suggest that production of NADPH by the TCA cycle is a key event in our proposed pathway, it is not yet clear how NADPH production corresponds to actual activity of the cyclegiven that metabolites can enter and exit the cycle at multiple points depending on nutritional conditionsnor how the cellular compartmentalization of NADPH production contributes to the transmission of the NADPH status to the ER

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