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Materials and methods: Glucagon-like peptide-1 receptor (GLP-1R) kinetic binding parameters, cyclic adenosine monophosphate (cAMP) signalling, endocytosis and recycling were measured using HEK293 and INS-1832/3 cells expressing human GLP-1R

Therefore, we sought a less-sensitive functional assay with reduced receptor expression levels to enable the optimization of efficacy-driven GLP-1R agonists for clinical development

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Studies show that GLP-1 in adults used with lifestyle changes, showed an average weight loss of about 6% of initial body weight over 12 weeks, and 12% was achieved by week 28