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The following data were collected: publication year, country and continent, study setting (e.g., hospital, private practice, academic clinic), sample size, age range, mean age, study design, population characteristics, intervention details, outcomes, and effect measures (e.g., serum B12 levels)

In Australia, it is prescription-only

Challenges include gastrointestinal side effects, nutritional deficiencies due to calorie reduction, muscle and bone loss, low long-term adherence with subsequent weight regain, and high costs, resulting in low cost-effectiveness

9C) showed strong representation of pathogenic Firmicutes lineages (Erysipelotrichaceae, Peptostreptococcales-Tissierellales, Christensenellaceae) and severe reduction of Bacteroidota in the VPA-ASD model