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Changing the delivery method can alter side effects, metabolic response, and risk profile

Data from other groups and our recent study have shown that endothelium and cardiac and vascular myocytes express a functional GLP-1R, and participate in the protective cardiovascular effects of GLP-1 analogues 11,36,37,38

There were also some improvements in surrogate markers of fibrosis measured by MRE (36% and 33% of patients in the 10 mg daily and 20 mg weekly arms, respectively, had 15% reduction in liver stiffness compared to 7% in the control arm) and pro-C3, as measured by adjusted percent improvement from baseline (30%, 21% and 1.9% in the 10 mg daily, 20 mg weekly, and placebo arm, respectively)

That sounds alarming, but it is normal for any rapid weight loss, and it is largely fixable