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For studies isolating GH effects without confounding stress hormone activation, Ipamorelin allows higher dosing (up to 300mcg) without cortisol elevation, whereas Hexarelin protocols rarely exceed 200mcg to avoid excessive cortisol response

This research is still in early stages, but the combination of topical convenience, rapid onset, steroid-comparable efficacy, and systemic immune modulation makes PEPITEM-derived tripeptides one of the most exciting developments in psoriasis peptide research