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10.3389/fcvm.2021.810791 24 CappettaD.De AngelisA.CiuffredaL

The reaction is reversible and GSH is a competitive inhibitor of GCS against glutamate [2830]

The rationale is mechanistic non-overlap: rather than two compounds acting through the same pathway with redundant effects, BPC-157 and TB-500 engage distinct targets the former operating through nitric-oxide-pathway and VEGFR2 modulation, the latter through actin-cytoskeleton regulation