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Treatment response depends on deficiency severity, route of administration, underlying cause, patient age, concurrent medical conditions, and medication interactions

With the possibility of each cell line receiving different amounts of the drug being discarded, we focused in understanding if the DNA repair capacity, as showed by the XPF knockdown in the most resistant lineage, could explain the different sensitivity to cisplatin among them

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The Biochemistry of Extraction The efficacy of a glandular product relies entirely on its processing