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12 ,
Unresolved lipotoxicity, oxidative stress, and ER stress ultimately trigger apoptosis of hepatocytes ( Figure 1B )
Considering the well-documented gonadotoxicity of platinum-based chemotherapeutics and the growing evidence supporting the antioxidative and anti-inflammatory properties of MEL and GSH, this study aims to explore a novel therapeutic strategy to mitigate chemotherapy-related ovarian toxicity
But unfortunately, most of these treatments recur after a short time
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