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95% of children exposed by 9 months Neurodevelopmental disorder prevalence: 1960s: 1 in 10,000 1980s: 1 in 2,000 Late 1990s: 1 in 200 2021: 1 in 44 1996-2010: 269% increase in prevalence 1998-2018: 787% increase in UK The dramatic rise began in the late 1980s and accelerated through the 1990s and 2000sapproximately 25-30 years after acetaminophen's widespread adoption in pregnancy

Oral Administration (Future) Amycretin Amycretin is being developed in both subcutaneous and oral formulations

The lower activity of ChaC2 may be partly attributed to flexible loop 2, acting as a gating function to achieve specificity for GSH binding and regulate a constant GSH degradation rate