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Patients with DKD who show clearly elevated urinary ferritin levels or increased exosomal ACSL4 expression may respond more strongly to the anti-ferroptotic effects of SGLT2 inhibitors and may gain greater renal benefit

6,7 As a protein playing a significant role in multiple cellular functions, modulation of TRX-1 expression and activity alters the metabolism from a physiological state to a pathological state leading to conditions such as cancer, and neurodegenerative and cardiovascular diseases

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