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Thiagarajah, K., Chee, H

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Semaglutide is a synthetic GLP-1 peptide produced using recombinant peptide synthesis techniques and designed to structurally mimic native human glucagon-like peptide-1 (GLP-1)

Clinical studies show that weight loss of 510% of body weight can significantly reduce knee pain, improve mobility, and slow the progression of osteoarthritis