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Adipose tissue strongly enhances GIP secretion [19] and GIP levels are high in obese people with T2DM

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In laboratory and animal studies, GLP-1 receptor agonists appear to reduce production of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), and interleukin-1 beta (IL-1)

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Avoid overly aggressive treatment of hypoglycemia

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The GLP-1 receptors can be found in the hypothalamus, hippocampus, and parts of the brains reward circuitry

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