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If injecting multiple peptides, use different injection sites and space them 15-30 minutes apart

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2 (download ZIP Tables of data used to produce plots

IGF-1 LR3 is modified at two positions (N-terminal 13-amino-acid extension and Arg3 substitution) to substantially reduce IGFBP-3 binding, extending preclinical activity duration well beyond the roughly 10 to 12 minutes seen with unbound native IGF-1