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This is the appropriate time to consider statin initiation, statin dose adjustment, or addition of ezetimibe based on the observed lipid response 7

In patients with T2DM who do not have atherosclerotic cardiovascular disease (ASCVD)/indicators of high-risk, HF, or CKD and who need to minimize hypoglycemia and/or promote weight loss, GLP-1 RAs are generally recommended as a second or third-line option as add-on to metformin therapy

The symptoms of lactic acidosis are severe and quick to appear, and usually occur when other health problems not related to the medicine are present and are very severe, such as a heart attack or kidney failure

A study published in July of 2023 suggests that berberine is one of those other GLP-1R agonists