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Larger subcutaneous injection volumes (above 0.5mL) can cause more local discomfort, swelling, and slower absorption

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Our results align with a recent systematic review 50 that found 9 of 15 studies profiling the microbiotas (vaginal, cervical, endometrial, peritoneal fluid, endometriotic lesion, and/or gut) identified Gram-negative bacterial taxa that were significantly enriched in people with endometriosis, which may provide additional support for a putative link between bacterial endotoxins/LPS (part of the outer membrane of Gram-negative bacteria) and endometriosis as proposed by the bacterial contamination hypothesis (reviewed in 38,39 )