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However, despite extensive research, the molecular details underlying the interaction of FOXO4 and p53 and the mode of action of FOXO4-DRI remain elusive

FIGURE 2 4.1 Systemic transport after nasal administration Nasal administration of drugs can direct the rapid systemic absorption of drugs by circumventing the hepatic first-pass metabolism and gastric degradation, allowing fast onset of pharmacological action ( via diffusion ( 4.2 Nose-to-brain transport after nasal administration Blood-brain barrier (BBB) is constructed through the networking of brain capillary endothelial cells that are held together by tight junctions, which segregates the blood perfusion into the CNS ( Currently, intranasal delivery is suggested as a promising alternative to invasive strategies because it can directly transport the molecules to the brain bypassing the BBB ( in vivo , and of peptide drugs, including insulin, vasopressin, melanocortin, angiotensin II, and oxytocin in humans was successfully accomplished ( The transport of molecules after the absorption in the nasal cavity is known to follow multiple pathways ( via olfactory and trigeminal nerve pathways circumventing the BBB ( After the passage through the mucus, paracellular and transcellular transport and extracellular diffusion can mediate the access to the CNS, which can occur in the epithelium of respiratory and olfactory mucosa ( 5 Methodology for CPP-mediated transepithelial delivery CPPs have emerged as novel vectors in promoting the transepithelial delivery of bioactive molecules, such as peptides and proteins, nucleic acids, and drug carriers like nanoparticles and liposomes ( 5.1 Types of CPPs and cargos in the transepithelial transport Several CPPs, including TAT-PTD, polyarginine, penetratin, transportan, and their derivatives, have been employed for the drug delivery through the nasal and intestinal epithelium

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