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The SURMOUNT-1 trial, which followed participants for 72 weeks, demonstrated that patients on the highest dose (15 mg) achieved an average weight loss of 20.9% from baseline, with weight loss continuing throughout most of the study period before stabilizing

Later studies have reported weight loss approaching 28% in some participants, which is comparable to results sometimes seen with bariatric surgery

Sermorelin, a GHRH analog, may support endogenous growth hormone release, which is closely linked to slow-wave sleep architecture

As weight loss medications like Wegovy and Ozempic rise in popularity across the United States, concerns are emerging about their safety, particularly for women who are pregnant or trying to conceive