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Further mechanistic studies have found that treatment with TMZ promoted cardiac Nrf2 expression, indicating that TMZ enhanced the clearance of oxidative stress by activating the GSH system through the Nrf2 signaling pathway [210]

Recently, our group studied the effect of low dose sodium selenite supplementation (multiple intraperitoneal injection of 4 g/kg body weight) on the 30-day survival of mice against the lethal dose (8 Gy) of WBI with -rays (Table 2) [50]

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Proper IM Injection Techniques When giving intramuscular B12 injections, its important to follow the right steps