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The effects are mediated by weight loss and insulin, both of which are reversible

van Dyck, C

These precedents highlight the need for indication-specific risk assessment and careful differentiation between mechanism-based toxicity and species-specific artifacts

In addition, the composition of multiple constituents of Pycnogenol , each having different benefits for human health, further explains its broad clinical application ( For the first time, this review aims to systematically summarize and discuss these gold standard RDP trials comparing the efficacy of Pycnogenol to placebo and giving explanations for the different effects with the help of the respective mechanisms of action