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Combination data with diet suggest complementary mechanisms, and reviews highlight continued medicinal-chemistry work to tune potency, selectivity, and exposure for future translational studies
, Diabetes Obes Metab 26(11):5272-5282 , USA , 2024 With daily dosing for 28 days, fat mass gain was suppressed by roughly 72% relative to control, glucose tolerance improved, and plasma cholesterol decreased
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