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If you are already struggling with nausea, vomiting, or stomach discomfort from your GLP-1 medication, adding alcohol is likely to make these symptoms significantly worse

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Effect of oral semaglutide compared with placebo and subcutaneous semaglutide on glycemic control (PIONEER program)

Because the drug binds to GLP-1 receptors in the brain, regulating appetite and reducing food intake, the once-weekly subcutaneous injectable is sometimes prescribed off-label for weight loss