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The FDA approves them based on a series of clinical trials that prove efficacy and most importantly safety

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& Chance, B

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Adequate B12 status is necessary for normal cellular function, but supraphysiological dosesbeyond correcting deficiencydo not demonstrably enhance metabolism in individuals with normal B12 levels

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This is why some formulation scientists recommend slightly acidic buffer solutions for peptide storage when long-term stability is needed

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