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Some variants have clear structural explanations for their loss-of-function, for example, variants can disrupt binding of carnitine (R471C/H/P), affect the Na + -binding site (N32S), disrupt the TM2-TM11 H-bonding network (S467C) or perturb gating residues conserved in OCTs/OATs (R169Q/P/W)
These are mainly related to the digestive system, such as nausea
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It's designed for once-weekly injection, but a growing number of users split their doses into smaller, more frequent injections
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