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Adsorptive-mediated transport at the BBB has also been exploited to target nanocarrier systems by using cationic lipids and cell penetrating peptides to increase binding and internalization at the brain capillary endothelium [29, 30], which has a highly negative surface charge [31]
The model development was done using non-linear mixed-effect modeling (NONMEM, edition 7, ICON Development Solutions, Ellicott City, MD, USA)
The two most effective bariatric procedures, Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) both result in enhanced meal-stimulated GLP-1 release which may be contributing to improvements in glucose metabolism and weight loss induced by these procedures
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