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Peptide therapy shows measurable improvements in sperm quality parameters, with specific peptides increasing sperm count by 15-40% and motility by 20-35% within 8-12 weeks of treatment

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As the discontinuation rates were also high with the twice daily danuglipron at the phase 2 obesity trial (as discussed above), twice daily danuglirpon formulation will not advance into phase 3 studies, but an improved once-daily formulation with an aim to improve tolerability profile is currently under assessment [27]