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Semaglutides FDA Approval to Treat MASH By inducing weight loss and improving metabolic health, semaglutide can decrease toxicity from fat accumulation and liver cell damage, allowing the liver to heal and achieve fibrosis regression, says Naim Alkhouri, MD, hepatologist and chief medical officer at Summit Clinical Research in San Antonio

Sources Food and Drug Administration (FDA): FDA Approves New Medication for Chronic Weight Management Molecular Metabolism Journal: Glucagon-like peptide 1 (GLP-1) American Gastroenterological Association (AGA): Biology of Incretins: GLP-1 and GIP Columbia Surgery: The Ozempic Effect: Everything You Need to Know About Medical Weight Loss Eli Lilly: Tirzepatide demonstrated significant and superior weight loss compared to placebo in two pivotal studies American Diabetes Association (ADA): Tirzepatide Reduces Appetite, Energy Intake, and Fat Mass in People With Type 2 Diabetes Important Medical Information and Disclaimers Important Current Status Update : As of March 19, 2025, the FDA has ended enforcement discretion for compounded tirzepatide