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Topical/cosmetic GHK-Cu Human studies on GHK-Cu have primarily focused on the topical route of administration
Some examples include: NADPH quinone dehydrogenase (NQO1), heme oxygenase 1 (HO1), the two subunits of glutamate-cysteine ligase (GCL), glutamate-cysteine ligase modifier (GCLM, the rate-limiting enzyme for GSH synthesis), SOD 1, CAT, sulfiredoxin, thioredoxin, and peroxiredoxin [68, 137, 162, 163]
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When used regularly in a soap formulation, it helps reduce the appearance of dark spots and promotes a more even skin tone
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