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Each should be reconstituted and injected separately
The water and the benzyl alcohol can freeze at slightly different rates, and upon thawing, they may not reintegrate into a perfectly homogenous 0.9% solution
Without any clear rationale, the study outcome measures were purposefully modified midtrial to alter the findings in favour of their hypothesis (549, 550)
This complete absence of tolerability-driven discontinuations represents a remarkable safety finding and indicates that even when mild side effects occurred, they were sufficiently manageable that participants chose to continue treatment
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