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Following carnitine acyl-carnitinemediated transfer of the CPT-1-generated fatty acyl-carnitines across the inner mitochondrial membrane, the fatty acyl-carnitine molecules are acted on by the inner mitochondria membrane carnitine palmitoyltransferase 2 (CPT-2 or CPT-II) regenerating the fatty acyl-CoA molecules (Figure 25-2)

Moreover, use of dulaglutide in people with T2DM is likely to confer additional renal benefits, and dulaglutide may be used in advanced chronic kidney disease at any eGFR level and without dose adjustment in contrast with most other noninsulin diabetes therapies (134, 135)

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