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Beyond the rapid clearance by the reticuloendothelial system (RES) which reduces bioavailability, the dense extracellular matrix and high interstitial fluid pressure within solid tumors severely restrict the deep penetration of nanorobots, often limiting therapeutic effects to the tumor periphery

Final Practical Checklist Monitor the lump for 24 weeks if it is small, tender, and appears linked to a recent infection

3 (download XLSX Excel workbook with raw data Source Data Table 1 (download XLSX Excel workbook with raw data Source Data Extended Data Fig

Fifth, consider starting with one agent at a low dose, then thoughtfully adding the second medication only after the first is well-tolerated