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Understanding Rebound Appetite and Metabolic Adaptation During Tapering As semaglutide doses decrease, GLP-1 receptor occupancy falls, restoring appetite signaling
At first, digestive troubles like nausea, bloating, or constipation might show up while your body gets used to the medication
This is the same active ingredient in the injectable version of Wegovy and became available for private prescription in June 2026
it's a predictable adaptation symptom that resolves in most users within the first four weeks of consistent dosing
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