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This may explain the delay between the initiation of metformin treatment and the onset of vitamin B12 deficiency
In a study of 10 healthy male volunteers, omeprazole, in doses of 20 mg-40 mg per day, caused a significant decrease in the oral absorption of methylcobalamin, vitamin B12
Mechanism of Action 5-Amino-1MQ inhibits NNMT, the enzyme that transfers a methyl group from SAM onto nicotinamide
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