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Over four draws from a 10mg vial, this can mean losing 0.04 to 0.2ml of solution, enough to reduce your final dose by 5 to 10%
Aminoglycosides, tetracyclines, and certain other antibiotics may alter gut microbiota composition, potentially affecting the small amount of vitamin B12 that is produced by colonic bacteria, though this is generally not clinically significant for patients receiving injectable B12 supplementation
Upon thawing, it may not re-dissolve evenly, creating an unstable solution that can damage peptides
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