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[1] Pigmentary dermatoses constitute one of the most common reasons for dermatology consultations and often lead to significant cosmetic concern and psychosocial distress, particularly in individuals with darker skin phototypes, where pigmentation tends to be more persistent and clinically prominent

Patients may not volunteer these symptoms unless asked directly

These effects can be troublesome and may require dose adjustments or treatment discontinuation

Clinical research priorities include properly designed human clinical trials with adequate sample sizes, appropriate controls, and validated outcome measures