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First isolated from cerebral venous blood in 1977, it gets its name from early research showing it could promote delta-wave sleep the deepest, most restorative stage of sleep associated with physical recovery and growth hormone release

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Monitor for excessive appetite suppression, unintended weight loss, increased heart rate or blood pressure, compounded gastrointestinal symptoms like nausea, and signs of dehydration

For the aortic samples from aged mice, first, the aortas from different treatment groups were excised and other tissues were removed, leaving only the aortic endothelium