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Developing a discontinuation plan should include establishing baseline measurements (weight, waist circumference, metabolic parameters), setting realistic expectations about weight maintenance challenges, creating a detailed lifestyle modification plan with specific, measurable goals, scheduling regular follow-up appointments (initially monthly, then quarterly), identifying triggers for earlier intervention if weight regain occurs, and discussing alternative pharmacological options if needed
Although research remains at the preclinical animal stage, the product has become an important tool for dissecting glucose metabolism disorders and diabetes and developing novel hypoglycemic agents, with its key advantage lying in nicotinamide pathway regulation and NAD+ stabilization
After LPS stimulation, the expression of GLP-1R was significantly increased compared with that of the sham group (Fig
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