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Description

Glucagon receptor activation by retatrutide increases energy expenditure by upregulating thermogenic pathways in brown adipose tissue, involving uncoupling protein 1 (UCP1) expression via cAMP-responsive elements

In women, it often develops on the lower legs

El-Sheikh AA, Rifaai RA

Several indirect mechanisms may explain why some individuals experience increased thirst while taking GLP-1 medications, even though thirst is not a direct pharmacologic effect of these agents