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Upregulated humoral factors, such as Midkine, further promote tubulointerstitial injury by accelerating local NETosis and subsequent tubular cell death (220)
The most common side effects are gastrointestinal, including nausea, vomiting, diarrhoea, and constipationsymptoms that can be particularly problematic in Parkinson's patients who often already experience autonomic dysfunction and gastroparesis
Stress management Cortisol and other stress hormones directly impair skin barrier function and promote Th2 immune deviation
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