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Plant Glutathione Synthetases: Structure, Function, and Product Diversity In the second step of glutathione synthesis, GS catalyzes the ATP-dependent addition of glycine to -glutamylcysteine (Figure 1)

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17,18 The most common offending drugs include antiepileptics (carbamazepine, phenytoin, lamotrigine, phenobarbital), allopurinol, sulfonamides (sulfasalazine, dapsone, trimethoprim-sulfamethoxazole), minocycline, vancomycin, and antituberculosis agents (isoniazid, rifampicin, ethambutol, pyrazinamide)