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Significant progress has been made in the development of PDAC vaccines over the past decade, demonstrating the safety and feasibility of personalized mRNA neoantigen vaccine production for treating resectable PDAC, as well as the combination of vaccines with other immunotherapies to induce more potent and durable T-cell responses [34]

To minimize these risks, tolerable upper intake levels (ULs) for zinc have been established by various organizations

References Assefa B, Mahmoud AM, Pfeiffer AFH, Birkenfeld AL, Spranger J, Arafat AM